Matt Lycas

From nanoscale synapses to whole-brain circuits — decoding neural organization with microscopy

Matt Lycas, Ph.D.

I am a Research Specialist in Janelia's AI Initiative where I develop expansion microscopy in the pursuit of connectomics research.

Applying quantitative imaging to expansion microscopy to achieve in situ estimation of protein abundance.

Observing pharmacological changes to the ultrastructure of the dopaminergic presynapse using advanced cryo-electron microscopy techniques.

Use of these tools to help examine the role of cristae in mitochondrial pearling and understand dynamic organelle behavior.

Description: Detailed protocols and methods for quantitative expansion microscopy techniques used in our research.

Includes: Step-by-step procedures, reagent lists, and videos.

View Protocol on GitHub

Interested in collaboration or microscopy methods development?

Email LinkedIn ResearchGate ORCID Google Scholar