Publications - Matt Lycas

1

Quantitative Expansion Microscopy for In Situ Estimation of Endogenous Target Abundance *

Lycas, M.D., Landoni, J.C., Noferi, B., Zimmerli, C.E., Douglass, K.M., Manley, S.

2026 Under Review bioRxiv 2026.01.18.700178

2

Brain-wide mapping reveals temporal and sexually dimorphic opioid actions

Vasylieva, I., Smith, R., Aravind, E., Pless, L.L., He, K., Ling, T., Kozel, J., Puig, S., Kedziora, K.M., Scarlett, J.J., Joseph, P.N., Lycas, M.D., Williams, B.R., Gamble, M.C., Gether, U., Logan, R.W., Freyberg, Z., Watson, A.M.

Communications Biology 2026 doi:10.1038/s42003-026-09730-8

3

Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum

Ejdrup, A., Dreyer, J.K., Lycas, M.D., Jørgensen, S.H., Robbins, T.W., Dalley, J., Herborg, F., Gether, U.

eLife 2026 doi:10.7554/eLife.105214

4

Pearling Drives Mitochondrial DNA Nucleoid Distribution

Landoni, J.C., Lycas, M.D., Macuada, J., Stepp, W., Jaccard, R., Obara, C.J., Moore, A.S., Hoffman, D., Lippincott-Schwartz, J., Marshall, W., Sturm, G., Manley, S.

Science 2026 doi:10.1126/science.adu5646

5

Membrane curvature association of amphipathic helix 8 drives constitutive endocytosis of GPCRs

Schmidt, J.H., Herlo, R., Rombach, J., Larsen, A.H., Stoklund, M., Perslev, M., Nielsen, T.T.E., Andersen, K.A., Klein Herenbrink, C., Lycas, M.D., Ejdrup, A.L., Christensen, N.R., Christensen, J.P., Salman, M., Herborg, F., Gether, U., Hauser, A.S., Bassereau, P., Perrais, D., Madsen, K.L.

Science Advances 2025 doi:10.1126/sciadv.adv1499

6

Chapter 11 — Dopamine transporters and the nanoscale organization of the dopamine axon

Ejdrup, A.L., Lycas, M.D., Herborg, F., Gether, U.

Handbook of Behavioral Neuroscience, Vol. 32, Elsevier 2025 Book Chapter doi:10.1016/B978-0-443-29867-7.00008-6

7

Ultrastructural Dynamics of Dopaminergic Presynaptic Release Sites revealed by Cryo-correlative Light and Electron Microscopy *

Lycas, M.D., Morado, D.R., Gether, U., Briggs, J.A.G., Erlendsson, S.

Journal of Cell Biology 2024 Accepted bioRxiv 2024.04.15.589543

8

DNA-PAINT adaptors make for efficient multiplexing *

Lycas, M.D., Manley, S.

Cell Reports Methods 2024 doi:10.1016/j.crmeth.2024.100801

9

Trifunctional linkers enable improved visualization of actin by expansion microscopy

Wen, G., Lycas, M.D., Jia, Y., Leen, V., Sauer, M., Hofkens, J.

ACS Nano 2023 doi:10.1021/acsnano.3c07510

10

Insulin-like growth factor 1 supplementation supports motor coordination and affects myelination in preterm pigs

Christiansen, L.I., Ventura, G.C., Holmqvist, B., Aasmul-Olsen, K., Lindholm, S.E.H., Lycas, M.D., Mori, Y., Secher, J.B., Burrin, D.G., Thymann, T., Sangild, P.T., Pankratova, S.

Frontiers in Neuroscience 2023 doi:10.3389/fnins.2023.1205819

11

Within-mice comparison of microdialysis and fiber photometry-recorded dopamine biosensor during amphetamine response

Ejdrup, A.L., Wellbourne-Wood, J., Dreyer, J.K., Guldhammer, N., Lycas, M.D., Gether, U., Hall, B.J., Sørensen, G.

ACS Chemical Neuroscience 2023 doi:10.1021/acschemneuro.2c00817

12

Behavioral encoding across timescales by region-specific dopamine dynamics

Jørgensen, S.H., Ejdrup, A.L., Lycas, M.D., Posselt, L.P., Madsen, K.L., Tian, L., Dreyer, J.K., Herborg, F., Sørensen, A.T., Gether, U.

PNAS 2023 doi:10.1073/pnas.2215230120

13

Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2 autoreceptor activity *

Lycas, M.D., Ejdrup, A.L., Sørensen, A.T., Haahr, N.O., Jørgensen, S.H., Guthrie, D.A., Støier, J.F., Werner, C., Newman, A.H., Sauer, M., Herborg, F., Gether, U.

Cell Reports 2022 doi:10.1016/j.celrep.2022.111431

14

Modeling the early stages of Alzheimer's disease by administering intracerebroventricular injections of human native amyloid beta oligomers to rats

Baerends, E., Soud, K., Folke, J., Pedersen, A.K., Henmar, S., Konrad, L., Lycas, M.D., Mori, Y., Pakkenberg, B., Woldbye, D.P.D., Dmytriyeva, O., Pankratova, S.

Acta Neuropathologica Communications 2022 doi:10.1186/s40478-022-01417-5

15

A density-based enrichment measure for assessing colocalization in single-molecule localization microscopy data

Ejdrup, A.L., Lycas, M.D., Lorenzen, N., Konomi, A., Herborg, F., Madsen, K.L., Gether, U.

Nature Communications 2022 doi:10.1038/s41467-022-32064-y

16

Cholestasis alters brain lipid and bile acid composition and compromises motor function in neonatal piglets

Henriksen, N.L., Hansen, S.H., Lycas, M.D., Pan, X., Eriksen, T., Johansen, L.S., Sprenger, R.R., Ejsing, C.S., Burrin, D.G., Skovgaard, K., Christensen, V.B., Thymann, T., Pankratova, S.

Physiological Reports 2022 doi:10.14814/phy2.15368

17

Dissociating reward sensitivity and negative urgency effects on impulsivity in the five-choice serial reaction time task

Toschi, C., El-Sayed Hervig, M., Burghi, T., Sell, T., Lycas, M.D., Moazen, P., Huang, L., Gether, U., Robbins, T.W., Dalley, J.W.

Brain and Neuroscience Advances 2022 doi:10.1177/23982128221102256

18

Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis

Andersen, R.C., Schmidt, J.H., Rombach, J., Lycas, M.D., Christensen, N.R., Lund, V.K., Stapleton, D.S., Pedersen, S.S., Olsen, M.A., Stoklund, M., Noes-Holt, G., Nielsen, T.T., Keller, M.P., Jansen, A.M., Herlo, R., Pietropaolo, M., Simonsen, J.B., Kjærulff, O., Holst, B., Attie, A.D., Gether, U., Madsen, K.L.

Journal of Clinical Investigation 2022 doi:10.1172/JCI144904

19

Disruption of the PDZ domain-binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation

Sørensen, G., Rickhag, M., Leo, D., Lycas, M.D., Ridderstrom, P.H., Weikop, P., Lilja, J.H., Rifes, P., Herborg, F., Woldbye, D., Wörtwein, G., Gainetdinov, R.R., Fink-Jensen, A., Gether, U.

Journal of Biological Chemistry 2021 doi:10.1016/j.jbc.2021.101361

20

Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease

Herborg, F., Jensen, K.L., Tolstoy, S., Arends, N.V., Posselt, L.P., Shekar, A., Aguilar, J.I., Lund, V.K., Erreger, K., Rickhag, M., Lycas, M.D., et al., Gether, U.

JCI Insight 2021 doi:10.1172/jci.insight.151496

21

Rab2 drives axonal transport of dense core vesicles and lysosomal organelles

Lund, V.K., Lycas, M.D., Schack, A., Andersen, R.C., Gether, U., Kjaerulff, O.

Cell Reports 2021 doi:10.1016/j.celrep.2021.108973

22

Dopaminergic neurons establish a distinctive axonal arbor with a majority of non-synaptic terminals

Ducrot, C., Bourque, M.J., Delmas, C.V.L., Racine, A.S., Guadarrama Bello, D., Delignat-Lavaud, B., Lycas, M.D., Fallon, A., Michaud-Tardif, C., Burke Nanni, S., Herborg, F., Gether, U., Nanci, A., Takahashi, H., Parent, M., Trudeau, L.E.

The FASEB Journal 2021 doi:10.1096/fj.202100201RR

23

Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter

Guthrie, D.A., Klein Herenbrink, C., Lycas, M.D., Ku, T., Bonifazi, A., DeVree, B.T., Mathiasen, S., Javitch, J.A., Grimm, J.B., Lavis, L., Gether, U., Newman, A.H.

ACS Chemical Neuroscience 2020 doi:10.1021/acschemneuro.0c00397

24

An amphipathic helix directs cellular membrane curvature sensing and function of the BAR domain protein PICK1

Herlo, R., Lund, V.K., Lycas, M.D., Jansen, A.M., Khelashvili, G., Andersen, R.C., Bhatia, V., Pedersen, T.S., Albornoz, P.B.C., Johner, N., Ammendrup-Johnsen, I., Christensen, N.R., Erlendsson, S., Stoklund, M., Larsen, J.B., Weinstein, H., Kjærulff, O., Stamou, D., Gether, U., Madsen, K.L.

Cell Reports 2018 doi:10.1016/j.celrep.2018.04.074

25

Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains

Rahbek-Clemmensen, T., Lycas, M.D., Erlendsson, S., Eriksen, J., Apuschkin, M., Vilhardt, F., Jørgensen, T.N., Hansen, F.H., Gether, U.

Nature Communications 2017 doi:10.1038/s41467-017-00790-3

26

Disruption of hippocampal synaptic transmission and long-term potentiation by psychoactive synthetic cannabinoid 'Spice' compounds: comparison with delta-9-tetrahydrocannabinol

Hoffman, A.F., Lycas, M.D., Kaczmarzyk, J.R., Spivak, C.E., Baumann, M.H., Lupica, C.R.

Addiction Biology 2017 doi:10.1111/adb.12334

27

Wheel running exercise attenuates vulnerability to self-administer nicotine in rats

Sanchez, V., Lycas, M.D., Lynch, W.J., Brunzell, D.H.